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Influence of live tularemia vaccine on chemical mutagenesis in white rats

Journal Article · · Sov. Genet. (Engl. Transl.); (United States)
OSTI ID:5649155
The influence of a single cutaneous immunization of live dry tularemia vaccine (TV) on mutagenesis induced by cyclophosphamide (CP), methyl nitrosourea (MNU), benzopyrene(BP), chloroprene (ChP), and 1,2,3,4-tetrachlorobutane (TCB) is studied for the first time on rats of the Wistar line. It is established that in rats immunized with TV, significant reduction in number of aberrant myelokaryocytes is noted on the 15th day after vaccination as compared to unimmunized animals which received the mutagens indicated. Possible mechanisms of the effect obtained are discussed.
Research Organization:
V. A. Fanardzhyan Scientific-Research Institute of Roentgenology and Oncology, Erevan, USSR
OSTI ID:
5649155
Journal Information:
Sov. Genet. (Engl. Transl.); (United States), Journal Name: Sov. Genet. (Engl. Transl.); (United States) Vol. 21:9; ISSN SOGEB
Country of Publication:
United States
Language:
English

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