Coal workers pneumoconiosis: in vitro study of the chemical composition and particle size as causes of the toxic effects of coal
Cells grown in vitro are inhibited to a greater extent by leachates of coal particles from a mine in Pennsylvania where the miners have a high incidence of Coal Workers' Pneumoconiosis than by leachates of coal of the same particle size but from a mine in Utah where the miners show a low prevalence of the disease. Leachates of respirable particles (1.5 ..mu..m and less) of the two coals caused markedly different responses in the cell culture system. The leachate from the Pennsylvania coal caused a growth depression while chemicals leached from the same size particles of the Utah coal stimulated cell growth. The concentration of selected metals in the leachates of the two coal samples differed. The results support the hypothesis that toxic substances leached from coal may be a factor in the etiology of CWP.
- Research Organization:
- Univ. of Cincinnati, OH
- OSTI ID:
- 5643318
- Journal Information:
- Environ. Res.; (United States), Vol. 20:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
01 COAL, LIGNITE, AND PEAT
COAL
TOXICITY
COAL MINERS
PNEUMOCONIOSES
COAL MINING
ENVIRONMENTAL EFFECTS
L CELLS
GROWTH
ETIOLOGY
BIOLOGICAL EFFECTS
CHEMICAL COMPOSITION
COMPARATIVE EVALUATIONS
EXPERIMENTAL DATA
IN VITRO
ISOLATED VALUES
LEACHING
PARTICLE SIZE
PENNSYLVANIA
RESPIRATORY SYSTEM
UTAH
CARBONACEOUS MATERIALS
CENTRAL REGION
DATA
DATA FORMS
DISEASES
DISSOLUTION
ENERGY SOURCES
FOSSIL FUELS
FUELS
INFORMATION
MINERS
MINING
NORTH AMERICA
NUMERICAL DATA
PERSONNEL
RESPIRATORY SYSTEM DISEASES
ROCKY MOUNTAIN REGION
SEPARATION PROCESSES
SIZE
USA
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
016000 - Coal
Lignite
& Peat- Health & Safety