Radiation induced osterogenic sarcoma in the rat as a model of hormone-responsive differentiated cancer

Journal Article · Sat Oct 01 04:00:00 EDT 1977 · Lab. Anim. Sci.; (United States)

OSTI ID:5638566

Ingleton, P M; Underwood, J C; Hunt, N H; Atkins, D; Giles, B; Coulton, L A; Martin, T J

An osteogenic sarcoma was induced in an inbred strain of the Sprague Dawley rat using seven serial injections of /sup 32/P-orthophosphate. The tumor was maintained by transplantation over a 3-year period in the same inbred strain. During this time it retained its bone-like differentiation. Tumor membranes and freshly isolated tumor cells also retained responsiveness to parathyroid hormone and to prostaglandins of adenylate cyclase and cyclic nucleotide formation respectively. The potencies of these agents and their analogues and metabolites were found to be proportional to their efficacies as bone resorbing agents. Thus, the tumor was shown to be a model for the study of hormone-responsiveness for tumor growth and differentiation, and also of the effects of agonists which act on bone-like cells.

• Research Organization: Univ. of Sheffield Medical School, England
• OSTI ID: 5638566
• Journal Information: Lab. Anim. Sci.; (United States), Journal Name: Lab. Anim. Sci.; (United States) Vol. 27:5; ISSN LBASA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DISEASES
HORMONES
ISOTOPES
LIGHT NUCLEI
MAMMALS
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
OSTEOSARCOMAS
PARATHORMONE
PEPTIDE HORMONES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PROSTAGLANDINS
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
SARCOMAS
SKELETAL DISEASES
TISSUES
VERTEBRATES