Deep venous thromboembolism in patients undergoing inguinal lymph node dissection for melanoma

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Ann. Surg.; (United States)

DOI:https://doi.org/10.1097/00000658-198111000-00016· OSTI ID:5638534

Arbeit, J M; Lowry, S F; Line, B R; Jones, D C; Brennan, M F

Deep venous thromboembolism (DVT) was studied in 44 patients with clinical Stage I, II, and III melanoma undergoing staging and therapeutic inguinal lymph node dissection. The ability of two noninvasive methods of surveillance, the phleborheograph (PRG) and the /sup 125/I fibrinogen scan to detect deep venous thrombosis was determined by comparison with prospective bilateral lower extremity venograms. In addition, the therapeutic impact, both beneficial and detrimental, of low dose heparin, 5000 units administered subcutaneously two hours prior to and every eight hours after operation was determined in a double blind study. The sensitivity of the PRG and /sup 125/I fibrinogen scan were both 20%. There were five deep venous thrombi, and two pulmonary emboli for a combined incidence of DVT of 13.6% for the entire patient population. However, there was no significant difference in the incidence of DVT between the two groups. The heparin-treated patients had an increased total volume (796 +/- 516 versus 388 +/- 208 ml; p less than 0.05), and duration of wound drainage (9 +/- 4 versus 13 +/- 6 days; p less than 0.05).

• Research Organization: Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
• OSTI ID: 5638534
• Journal Information: Ann. Surg.; (United States), Journal Name: Ann. Surg.; (United States) Vol. 194:5; ISSN ANSUA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANTICOAGULANTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BLOOD COAGULATION FACTORS
BLOOD VESSELS
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COAGULANTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FIBRINOGEN
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
HEPARIN
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LYMPH NODES
LYMPHATIC SYSTEM
MEDICINE
MELANOMAS
MUCOPOLYSACCHARIDES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATIENTS
POLYSACCHARIDES
PROTEINS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
SACCHARIDES
SCINTISCANNING
THROMBOSIS
VASCULAR DISEASES
VEINS