Long-term potentiation in the hippocampal slice: evidence for stimulated secretion of newly synthesized proteins

Journal Article · Mon Jun 01 04:00:00 EDT 1981 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7233208· OSTI ID:5637923

Duffy, C; Teyler, T J; Shashoua, V E

Long-term potentiation of the hippocampal slice preparation results in an increase in the incorporation of labeled valine into the proteins destined for secretion into the extracellular medium. Double-labeling methods established that the increased secretion of the labeled proteins was limited to the potentiated region of a slice; incorporation of labeled valine was increased in the hippocampus if potentiation was through the Schaffer collaterals and in the dentate if potentiation was through the perforant path. Controls for nonspecific stimulation showed no changes. There appears to be a link between long-term potentiation and the metabolic processes that lead to protein synthesis in the hippocampal slice system.

• OSTI ID: 5637923
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 212:4499; ISSN SCIEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
BIOCHEMICAL REACTION KINETICS
BIOCHEMISTRY
BIOSYNTHESIS
BODY
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
KINETICS
LABELLED COMPOUNDS
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
PROTEINS
REACTION KINETICS
SAMPLE PREPARATION
SECRETION
SYNTHESIS
VALINE