Inspiratory flow and intrapulmonary gas distribution
The effect of flow of inspired gas on intrapulmonary gas distribution was examined by analysis of regional pulmonary /sup 133/Xe clearances and of total pulmonary /sup 133/Xe clearance measured at the mouth after equilibration of the lungs with /sup 133/Xe. Five awake healthy volunteers (24 to 40 yr of age) and another 5 healthy, anesthetized-paralyzed volunteers (26 to 28 yr of age) were studied while they were in the right lateral decubitus position. The awake subjects were studied at 3 inspiratory flows (0.4, 0.7, and 1.0 L/s) and the anesthetized-paralyzed subjects at 4 inspiratory flows (0.2, 0.5, 1.1, and 1.6 L/s). Interregional differences in /sup 133/Xe clearances along the vertical axis were significantly less during anesthesia-paralysis and mechanical ventilation than during spontaneous breathing in the awake state. No differences in the regional or total pulmonary /sup 133/Xe clearances were detected at these different flows in either of the two states, i.e., the difference between the awake and anesthetized-paralyzed states persisted.
- Research Organization:
- Department of Anesthesiology, Mayo Clinic and Mayo Foundation, Rochester, MN
- OSTI ID:
- 5635378
- Journal Information:
- Am. Rev. Respir. Dis.; (United States), Vol. 124:4
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
FLOW RATE
BIOLOGICAL EFFECTS
LUNGS
RADIONUCLIDE KINETICS
XENON 133
LUNG CLEARANCE
TISSUE DISTRIBUTION
ANESTHESIA
MAN
RESPIRATION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
EVEN-ODD NUCLEI
EXCRETION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ORGANS
PRIMATES
RADIOISOTOPES
RESPIRATORY SYSTEM
VERTEBRATES
XENON ISOTOPES
560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)
550601 - Medicine- Unsealed Radionuclides in Diagnostics