Synthesis, NMR characterization, and a simple application of lithium borotritide

Journal Article · Fri Dec 13 04:00:00 EST 1996 · Journal of Organic Chemistry

DOI:https://doi.org/10.1021/jo961239u· OSTI ID:563468

Than, Chit; Morimoto, Hiromi ^[1]; Andres, H ^[2]

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1. Lawrence Berkeley National Lab., CA (United States)
2. Sandoz Pharma Ltd., Basle (Switzerland); and others

LiBH{sub 4} is a powerful and selective reagent for regiospecific reduction reactions. A simple synthesis of LiB{sup 3}H{sub 4} at near theoretical specific radioactivity is reported. The authors have treated Li{sup 3}H synthesized from tritium gas ({sup 3}H{sub 2}, {approximately}98%) with BBr{sub 3} to produce LiB{sup 3}H{sub 4} (specific activity = 4120 GBq/mmol = 110 Ci/mmol. The maximum theoretical specific activity of LiB{sup 3}H{sub 4} is 4252 GBq/mmol = 115.04 Ci/mmol; 1 matom of {sup 3}H = 1063 GBq = 28.76 Ci.) The tritium labeling performance of the reagent was tested by an exemplary reduction of 2-naphthaldehyde to 2-naphthalenemethanol. LiB{sup 3}H{sub 4} and the reduction products were characterized by a combination of {sup 1}H, {sup 3}H, and {sup 11}B NMR techniques, as appropriate. 35 refs., 1 fig.

• DOE Contract Number: AC03-76SF00098
• OSTI ID: 563468
• Journal Information: Journal of Organic Chemistry, Journal Name: Journal of Organic Chemistry Journal Issue: 25 Vol. 61; ISSN JOCEAH; ISSN 0022-3263
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
ALDEHYDES
BOROHYDRIDES
CHEMICAL PREPARATION
LABELLING
LITHIUM COMPOUNDS
NUCLEAR MAGNETIC RESONANCE
REDUCTION
TRITIUM COMPOUNDS