Reduction and repopulation of recipient T4+ and T8+ T-lymphocytes in allogeneic bone marrow transplantation
Journal Article
·
· Exp. Hematol.; (United States)
In eight recipients of allogeneic bone marrow grafts who had sex-mismatched donors, the reduction and subsequent repopulation of T4+ and T8+ T-lymphocytes of recipient origin were studied. The origin of the donor-recipient T4+ and T8+ T cells was studied using quinacrine staining of Y chromatin combined with T-cell typing for T4 and T8. Following chemoradiotherapy and bone marrow transplantation (BMT), T cells reached their nadir at a median of five (range 1-8) days after BMT. T8+ T cells decreased at a faster rate from the peripheral blood than T4+ T cells. The first T cells that appeared in the circulation at day 12 were predominantly T4+, and a large number of them were of recipient origin. Thereafter, they gradually decreased, and the numbers of T cells of donor origin increased. In the patients who had no or only minor complications, T4+ and T8+ T cells of donor origin repopulated the blood at similar rates. This pattern, however, was modified by severe graft-versus-host disease or by cytomegalovirus infection.
- Research Organization:
- Univ. Hospital, Leiden, The Netherlands
- OSTI ID:
- 5633580
- Journal Information:
- Exp. Hematol.; (United States), Journal Name: Exp. Hematol.; (United States) Vol. 2; ISSN EXHMA
- Country of Publication:
- United States
- Language:
- English
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Tue Jul 01 00:00:00 EDT 1986
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Tue Dec 31 23:00:00 EST 1985
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·
OSTI ID:5675323
Related Subjects
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
RECOVERY
SOMATIC CELLS
THERAPY
TISSUES
TRANSPLANTS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REGENERATION
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
HEMATOPOIETIC SYSTEM
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
RECOVERY
SOMATIC CELLS
THERAPY
TISSUES
TRANSPLANTS