Effect of orally administered dioctyltin dichloride on murine immunocompetence

Journal Article · Tue Apr 01 04:00:00 EST 1986 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(86)80067-6· OSTI ID:5632015

Miller, K; Maisey, J; Nicklin, S

The immunotoxicological effects of di(n-octyl)tin dichloride (DOTC) in the mouse were measured using a well-defined system to monitor alterations in immune responsiveness towards both self and heterologous cell membrane components. Oral weekly administration of DOTC caused a suppression of the anti-self erythrocyte antibody response. The humoral response against rat erythrocytes was also diminished. Although humoral responsiveness was affected only at a dose level which caused thymic atrophy (500 mg/kg body wt) the delayed type hypersensitivity reaction to oxazolone, a measure of cell-mediated immunity, was not affected. These data indicate that DOTC can suppress specific aspects of murine immunocompetence and may be relevant in designing studies for assessing possible hazards associated with environmental chemicals.

• Research Organization: British Industrial Biological Research Association, Carshalton, England
• OSTI ID: 5632015
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 39:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MARKERS
CHLORIDES
CHLORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
IMMUNOSUPPRESSION
MAMMALS
MICE
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
RODENTS
TIN CHLORIDES
TIN COMPOUNDS
TIN HALIDES
TOXICITY
VERTEBRATES