Pathological effects of in utero methylmercury exposure on the cerebellum of the golden hamster: residual effects on the adult cerebellum-part 2

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(81)90205-X· OSTI ID:5627758

Reuhl, K R ^[1]; Chang, L W; Townsend, J W

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1. National Research Council Lab., Ottawa, Ontario

The long-term effects of prenatal methylmercury exposure were studied in the golden hamster (Mesocricetus auratus). Pregnant animals were either 10 mg/kg methylmercury on gestational day 10 or 2 mg/kg on gestational days 10-15. Animals from treated and control litters were sacrificed as adults and cerebella examined by light and electron microscopy. Focal areas of astrogliosis were observed in the molecular layer of treated animals. Sequellae of previous injury, characterized primarily by abundant residual bodies, were observed in the perikarya and dendrites of granule and Purkinje neurons. Degenerative change of myelinated axons was observed. Possible hypotheses for continued neuronal degeneration in prenatally exposed animals are discussed.

• OSTI ID: 5627758
• Journal Information: Environ. Res.; (United States), Vol. 26:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CEREBELLUM
INJURIES
METHYLMERCURY
BIOLOGICAL EFFECTS
ELECTRON MICROSCOPY
HAMSTERS
PATHOLOGY
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
MAMMALS
MICROSCOPY
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)