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Biochemical mechanisms and clusters of damage for high-let radiation

Conference · · Advances in Space Research
 [1];  [1]
  1. Lawrence Berkeley Laboratory (LBL), Berkeley, CA (United States)
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Using mechanisms of indirect and direct radiation, a generalized theory has been developed to account for strand break yields by high-LET particles. The major assumptions of this theory are: (1) damage at deoxyribose sites results primarily in strand break formation and (2) damage to bases leads to a variety of base alterations. Results of the present theory compare well with cellular data without enzymatic repair. As an extension of this theory, we show that damage clusters are formed near each double strand break for high-LET radiation only. For 10 MeV/n (LET = 450 keV/μm) neon ions, the results show that on average there are ~3 additional breaks and ~3 damaged bases formed near each double strand break. For 100 MeV/n helium ions (LET = 3 keV/μm), less than 1% of the strand breaks have additional damage within 10 base pairs.
Research Organization:
Lawrence Berkeley Laboratory (LBL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
DOE Contract Number:
AC03-76SF00098
OSTI ID:
5625676
Report Number(s):
LBL--30023; CONF-9006220--7; ON: DE91012335
Conference Information:
Journal Name: Advances in Space Research Journal Issue: 2-3 Journal Volume: 12
Country of Publication:
United States
Language:
English

References (11)

Radiobiological effects of high-let particles: DNA strand breaks journal August 1989
DNA Damage Produced by Ionizing Radiation in Mammalian Cells: Identities, Mechanisms of Formation, and Reparability book January 1988
Theoretical consideration of the chemical pathways for radiation-induced strand breaks journal January 1986
Quantitative Determination of the Contribution of Indirect and Direct Radiation Action to the Production of Lethal Lesions in Mammalian Cells journal December 1985
Characterization of Hydroxyl Radical-induced Damage after Sparsely and Densely Ionizing Irradiation journal January 1985
Production of DNA Strand Breaks by Direct Effects of Heavy Charged Particles journal February 1990
The Formation of Strand Breaks in DNA after High-LET Irradiation: A Comparison of Data fromin Vitroand Cellular Systems journal January 1990
Optimised parameters for A-DNA and B-DNA journal June 1972
Track Structure Analysis of Ultrasoft X-rays Compared to High- and Low-LET Radiations journal January 1989
A Method of Calculating Initial DNA Strand Breakage Following the Decay of Incorporated125I journal January 1988
Theory of the chemical effects of high-energy electrons journal October 1978

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560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AQUEOUS SOLUTIONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHARGED PARTICLES
CHEMICAL RADIATION EFFECTS
CHEMISTRY
COLLISIONS
DATA
DISPERSIONS
DNA
DNA BASE TRANSITIONS
ELECTRONS
ELEMENTARY PARTICLES
ENERGY RANGE
ENERGY TRANSFER
EV RANGE
EV RANGE 100-1000
FERMIONS
HELIUM IONS
HYDROXYL RADICALS
INFORMATION
ION COLLISIONS
ION-MOLECULE COLLISIONS
IONIZING RADIATIONS
IONS
LEPTONS
LET
MATHEMATICAL MODELS
MIXTURES
MOLECULE COLLISIONS
MONTE CARLO METHOD
NEON IONS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
PARTICLE TRACKS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RADICALS
SOLUTIONS
STRAND BREAKS
TESTING
THEORETICAL DATA
THREE-DIMENSIONAL CALCULATIONS
VALIDATION