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Definitive radiotherapy of prostatic cancer: the Norwegian Radium Hospital's experience (1976-1982)

Journal Article · · Prostate (N.Y.); (United States)
; ;
During the years 1976 to 1982 definitive curatively aimed radiotherapy to the primary tumor was given to 53 patients with prostatic cancer confined to the true pelvis (T0, 2; T1-2, 19; T3, 24; T4, 8; N0, 18; N+, 2; Nx, 33); all patients were of the Mo-category. The pelvic lymph nodes received a total dose of 2 Gy X 25 by means of an anterior and posterior radiation field. The prostatic gland was irradiated by an additional booster dose of 2 Gy X 10 given to a perineal field. Twenty-four patients have relapsed after their prostatic radiotherapy, only three of them within the irradiated area. For the patients with T0-T2 tumors, the 5-year crude survival was 69%, whereas it was only 37% for patients with T3 tumors. Thirty-five patients developed intestinal (26 patients) and/or urogenital (23 patients) radiation side effects. In three patients a colostomy had to be performed owing to rectal stricture or fistula. The poor survival after radiotherapy in the present series is probably due to a high incidence of unrecognized pelvic lymph node metastases. In the future only prostatic cancer patients without pelvic lymph node spread will be considered candidates for definitive radiotherapy. An optimal radiation technique is mandatory in order to avoid major radiotherapy-induced toxicity.
Research Organization:
Norwegian Radium Hospital, Oslo
OSTI ID:
5625612
Journal Information:
Prostate (N.Y.); (United States), Journal Name: Prostate (N.Y.); (United States) Vol. 11:1; ISSN PRSTD
Country of Publication:
United States
Language:
English

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Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
DOSES
EUROPE
GLANDS
INJURIES
LYMPH NODES
LYMPHATIC SYSTEM
MALE GENITALS
MEDICINE
METASTASES
NEOPLASMS
NORWAY
NUCLEAR MEDICINE
ORGANS
PATIENTS
PROSTATE
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SCANDINAVIA
SIDE EFFECTS
SURVIVAL CURVES
THERAPY
WESTERN EUROPE