Intracellular metallothionein concentration and the rate of zinc or cadmium influx and MT mRNA accumulation in a CHO Cd sup r variant
Journal Article
·
· Experimental Cell Research; (United States)
- Johns Hopkins Univ., Baltimore, MD (United States)
The regulation of metallothionein (MT) gene expression in a cadmium resistant CHO cell line which overproduces MT was examined in this study. The results show that MT and mRNA levels reach a maximum 24-30 h after a primary zinc exposure and, subsequently, MT mRNA concentrations decline. This decrease in MT mRNA levels can be correlated with the accumulation of metallothionein and decreased rates of zinc and cadmium uptake.
- OSTI ID:
- 5622926
- Journal Information:
- Experimental Cell Research; (United States), Journal Name: Experimental Cell Research; (United States) Vol. 185:1; ISSN ECREA; ISSN 0014-4827
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMISTRY
CADMIUM 109
CADMIUM COMPOUNDS
CADMIUM ISOTOPES
CHEMISTRY
CHO CELLS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GENE REGULATION
INTERMEDIATE MASS NUCLEI
ISOTOPES
MESSENGER-RNA
METALLOPROTEINS
METALLOTHIONEIN
MUTAGENESIS
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RNA
UPTAKE
YEARS LIVING RADIOISOTOPES
ZINC 65
ZINC COMPOUNDS
ZINC ISOTOPES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMISTRY
CADMIUM 109
CADMIUM COMPOUNDS
CADMIUM ISOTOPES
CHEMISTRY
CHO CELLS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GENE REGULATION
INTERMEDIATE MASS NUCLEI
ISOTOPES
MESSENGER-RNA
METALLOPROTEINS
METALLOTHIONEIN
MUTAGENESIS
NUCLEI
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
RADIOISOTOPES
RNA
UPTAKE
YEARS LIVING RADIOISOTOPES
ZINC 65
ZINC COMPOUNDS
ZINC ISOTOPES