(Radiolabeled androgens and progestins as imaging agents for tumors of the prostate and breast)

Technical Report · Tue Jan 01 04:00:00 EST 1991

DOI:https://doi.org/10.2172/5622070· OSTI ID:5622070

Katzenellenbogen, J A

The specific aims of the previous grant application can be summarized as follows: Synthesize fluorine-substituted progestins from the following high affinity classes: R5020 (promegestone), norgestrel, RU486, and retroprogestins; Synthesize fluorine-substituted androgens from the following high affinity classes: mibolerone, R1881 (metribolone) and 2-oxometribolone; Evaluate the receptor binding and non-specific binding of these fluorosteroids by in vitro binding assays; Develop and optimize fluoride ion substitution reactions suitable for the rapid, efficient and convenient preparation of these fluorosteroids in high specific activity, F-18 labeled form; and Evaluate the target tissue uptake of the F-18 labeled androgens and progestins in experimental animals.

• Research Organization: Illinois Univ., Urbana, IL (United States)
• Sponsoring Organization: DOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-86ER60401
• OSTI ID: 5622070
• Report Number(s): DOE/ER/60401-T2; ON: DE92008729
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AFFINITY
ANDROGENS
ANDROSTANES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC USES
DISEASES
DISTRIBUTION
DOCUMENT TYPES
ELECTRON CAPTURE RADIOISOTOPES
FLUORINE 18
FLUORINE ISOTOPES
GLANDS
HEAVY NUCLEI
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
IMAGES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
MALE GENITALS
MAMMARY GLANDS
NANOSEC LIVING RADIOISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROGRESS REPORT
PROSTATE
RADIOISOTOPES
RHENIUM 186
RHENIUM ISOTOPES
STEROID HORMONES
STEROIDS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TESTOSTERONE
TISSUE DISTRIBUTION
USES
YEARS LIVING RADIOI
YEARS LIVING RADIOISOTOPES