Distribution of radiation sensitivities for human tumor cells of specific histological types: comparison of in vitro to in vivo data
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The radiosensitivities of human tumor cell lines, grouped into 6 histological categories, have been studied using data from the published literature. The parameters alpha, beta, n, D0, D, and the surviving fraction to 2 Gy (S2) and 8 Gy (S8) were calculated. Only the two parameters mainly derived from the initial part of the survival curve, alpha and D, together with S2, provided data which were correlated with the clinical radioresponsiveness of each histological group. Thus, there are intracellular factors which influence clinical radioresponsiveness whose relative importance varies from one histological cell type to another. The value of D gave the most precise characterization of the average group radiosensitivity. It was possible to compare the in vivo radiosensitivities of non-severely hypoxic cells with those of tumor cells irradiated in vitro for 7 tumor lines grown as xenografts in mice. The average radiosensitivity was 1.9 times less in vivo than in vitro. This difference indicates that, in addition to the intrinsic factors of radioresistance demonstrated in vitro, and independently of severe hypoxia, there are other factors which specifically reduce radiosensitivity in vivo.
- Research Organization:
- Institut Gustave-Roussy, Villejuif, France
- OSTI ID:
- 5618015
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
COMPARATIVE EVALUATIONS
DISEASES
IN VITRO
IN VIVO
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
COMPARATIVE EVALUATIONS
DISEASES
IN VITRO
IN VIVO
MAMMALS
MEDICINE
MICE
NEOPLASMS
NUCLEAR MEDICINE
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
RODENTS
SURVIVAL TIME
THERAPY
TRANSPLANTS
TUMOR CELLS
VERTEBRATES