Altered DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells

Journal Article · Tue Jan 01 04:00:00 EST 1985 · KROC Found. Ser.; (United States)

OSTI ID:5616908

Painter, R B

DNA synthesis in cells from ataxia-telangiectasia (AT) patients differs from that in normal cells in two principal ways. In unirradiated cultures, AT cells have a lower inherent rate of DNA synthesis (and, therefore, a longer S phase) than normal cells and, in cultures exposed to ionizing radiation, DNA synthesis is not inhibited as it is in normal cells; this radioresistant DNA synthesis is due to completely resistant DNA chain elongation and partially resistant DNA replicon initiation. It is probable that the defects in DNA synthesis in irradiated and unirradiated cells are related and are at least partially involved in the pathogenesis of this syndrome.

• OSTI ID: 5616908
• Journal Information: KROC Found. Ser.; (United States), Journal Name: KROC Found. Ser.; (United States); ISSN KFSED
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL CYCLE
CONGENITAL DISEASES
CONNECTIVE TISSUE CELLS
DISEASES
DNA REPLICATION
FIBROBLASTS
NUCLEIC ACID REPLICATION
PATHOGENESIS
RADIATION EFFECTS
RADIOSENSITIVITY
SOMATIC CELLS
VASCULAR DISEASES