Pathogenic mechanism in lung fibrosis. [Synergistic effects of BHT, O/sub 2/, and x rays in mice]
The purpose of the study was to examine whether an interaction between two agents causing alveolar epithelial damage would produce lung fibrosis. In mouse lung, intraperitoneal injection of the antioxidant butylated hydroxytoluene causes diffuse alveolar type I cell necrosis, followed by proliferation of type II alveolar cells. In animals exposed to 70% O/sub 2/ or 100-200 rad x rays during the phase of type II cell proliferation following BHT, diffuse interstitial lung fibrosis developed within 2 weeks. Quantitative analysis of the lungs for hydroxyproline showed that the interaction between BHT and O/sub 2/ or x rays was synergistic. If exposure to O/sub 2/ or x rays was delayed until epithelial recovery was complete, no fibrosis was seen. Abnormally high levels of lung collagen persisted up to 6 months after one single treatment with BHT and 100 rad x rays. A commonly seen form of chronic lung damage may thus be caused by an acute interaction between a bloodborne agent which damages the alveolar cell and a toxic inhalant or x rays, provided a critically ordered sequence of exposure is observed.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- Sponsoring Organization:
- USDOE Environment and Safety
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5616653
- Report Number(s):
- CONF-790249--1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Applied Studies-- Radiation Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
AMINES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
ANTIOXIDANTS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BODY AREAS
CARBOXYLIC ACIDS
CHEST
COLLAGEN
CRYOGENIC FLUIDS
DATA
DATA FORMS
DELAYED RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTS
EXPERIMENTAL DATA
FIBROSIS
FLUIDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
HYDROXYPROLINE
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LOCAL IRRADIATION
LUNGS
MAMMALS
MICE
NONMETALS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN
PATHOLOGICAL CHANGES
PROTEINS
PYRROLES
PYRROLIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RECOVERY
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
RODENTS
SCLEROPROTEINS
SYNERGISM
TIME DEPENDENCE
VERTEBRATES
X RADIATION