Changes in surface structure and concanavalin A-binding capacity of urothelium in the mouse bladder after whole-body neutron irradiation
A broad overview has been compiled of the literature on the effects of radiation on urinary bladder and on selected cell surface markers that may give information on the pathobiological status of the urinary bladder urothelium. Scanning electron microscopy and immunogold labelling have been used in this study which examines the early (6h to 12 day) radiation response of the mouse urinary bladder following whole-body neutron irradiation. Experimentally, after 5 Gy neutron irradiation, changes in the urothelium include surface morphological abnormalities and enhanced concanavalin A surface binding. These changes were most obvious 1 to 5 days post-irradiation, but lessened in their extent from 5 to 12 days after treatment.
- Research Organization:
- Imperial Cancer Research Fund, London, England
- OSTI ID:
- 5616161
- Journal Information:
- Scanning Electron Microsc.; (United States), Journal Name: Scanning Electron Microsc.; (United States)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLADDER
BIOLOGICAL RADIATION EFFECTS
EPITHELIUM
CHEMICAL BONDS
CONCANAVALIN
MICE
NEUTRONS
WHOLE-BODY IRRADIATION
AGGLUTININS
ANIMAL TISSUES
ANIMALS
ANTIBODIES
BARYONS
BIOLOGICAL EFFECTS
BODY
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FERMIONS
HADRONS
HEMAGGLUTININS
IRRADIATION
LECTINS
MAMMALS
NUCLEONS
ORGANS
RADIATION EFFECTS
RODENTS
TISSUES
URINARY TRACT
VERTEBRATES
560152* - Radiation Effects on Animals- Animals