Reduction of 85Sr, 137Cs, 131I and 141Ce retention in rats by simultaneous oral administration of calcium alginate, ferrihexacyanoferrate(II), KI and Zn-DTPA

Journal Article · Fri Nov 01 00:00:00 EST 1985 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198511000-00017· OSTI ID:5615695

Kargacin, B; Kostial, K

The effect of simultaneous oral administration of a mixture of calcium alginate, ferrihexacyanoferrate(II) and KI and of the chelating agent zinc diethylenetriaminepentaacetate (Zn-DTPA) on the retention of radioactive Sr, Cs, I and Ce was investigated in 7-week-old female rats. The respective antidotes were administered in food during the first three days of the experiment and the radionuclides were administered on the second day of the experiment. The radionuclide retention was determined in the whole body, carcass, gut, liver, kidneys and respective critical organs six days after oral administration of 85Sr, 137Cs, 131I and intraperitoneal administration of 141Ce and one day after oral administration of 141Ce. Simultaneous oral administration of the four therapeutic agents reduced the retention of radioactive Sr, Cs and I administered orally and Ce applied intraperitoneally. Zn-DTPA did not diminish efficacy of antidotes from the mixture nor did the mixture significantly alter the effect of Zn-DTPA. Simultaneous oral administration of calcium alginate, ferrihexacyanoferrate(II), KI and Zn-DTPA might present a convenient method for delayed therapy especially in cases of prolonged increased environmental exposure to several radionuclides.

• OSTI ID: 5615695
• Journal Information: Health Phys.; (United States), Vol. 5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CERIUM 141
RETENTION
CESIUM 137
IODINE 131
STRONTIUM 85
ALGINATES
DECONTAMINATION
DTPA
FERROCYANIDES
KIDNEYS
LIVER
ORAL ADMINISTRATION
RADIATION PROTECTION
RATS
STOMACH
TISSUE DISTRIBUTION
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CERIUM ISOTOPES
CESIUM ISOTOPES
CHELATING AGENTS
CLEANING
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IRON COMPLEXES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RODENTS
STRONTIUM ISOTOPES
TRANSITION ELEMENT COMPLEXES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)