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Effect of disulfiram pretreatment on the tissue distribution, macromolecular binding, and excretion of (U-1,2-14C)dichloroethane in the rat

Journal Article · · Drug Metab. Dispos.; (United States)
OSTI ID:5614428
; ;
The effect of disulfiram (DSF) pretreatment on the distribution of (14C)ethylene dichloride (EDC) in selected organs and/or tissues of control and EDC-pretreated rats was studied. The presence of EDC metabolites and their binding to an acid-insoluble extract of the tissues, as well as purified protein and DNA, were evaluated. Dietary DSF was found to modulate the distribution, excretion, and macromolecular binding of EDC and/or its metabolites at 4 and 24 hr following ip administration. The urinary excretion of (14C)EDC metabolites was not affected by subchronic inhalation exposure to nonradiolabeled EDC. However, DSF pretreatment increased the fat deposition of EDC and decreased the urinary excretion of its metabolites. DSF also increased the binding of EDC metabolites to DNA and decreased the binding to protein in the liver, kidneys, spleen, and testes. However, prior exposure to EDC alone increased the binding of its metabolites to DNA in the kidneys only.
Research Organization:
Univ. of Cincinnati, OH
OSTI ID:
5614428
Journal Information:
Drug Metab. Dispos.; (United States), Journal Name: Drug Metab. Dispos.; (United States) Vol. 1; ISSN DMDSA
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CARBON 14 COMPOUNDS
CHEMICAL BONDS
CHLORINATED ALIPHATIC HYDROCARBONS
CLEARANCE
DISEASES
DISTRIBUTION
DNA
DRUGS
EXCRETION
HALOGENATED ALIPHATIC HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLITES
NEOPLASMS
NUCLEIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES