Radiation sensitivity of Bloom's syndrome lymphocytes during S and G2 phases
Journal Article
·
· Cancer Genet. Cytogenet.; (United States)
In order to study chromosome sensitivity of Bloom's syndrome (BS) cells in relation to the replication stage, gamma-ray irradiation was performed immediately before adding bromodeoxyuridine (BrdU) to lymphocyte cultures of one BS patient and of one control. It was found that BS cells are much more sensitive to the irradiation than control cells at the end of S and at G2 phases. The rate of induction of chromosome breaks is significantly increased and that of chromatid breaks and exchanges is also increased, though to a lesser degree. Our results also favor the existence of a cell subpopulation in BS characterized by a slow cycle, a high spontaneous chromosome aberration rate, and a high radiation sensitivity.
- Research Organization:
- Institut Curie, Paris, France
- OSTI ID:
- 5608980
- Journal Information:
- Cancer Genet. Cytogenet.; (United States), Journal Name: Cancer Genet. Cytogenet.; (United States) Vol. 16:2; ISSN CGCYD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMETABOLITES
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BROMOURACILS
BUDR
CELL CULTURES
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
CONNECTIVE TISSUE CELLS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HEREDITARY DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTATIONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PYRIMIDINES
RADIOSENSITIVITY
RIBOSIDES
SOMATIC CELLS
URACILS
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIMETABOLITES
AZINES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
BROMOURACILS
BUDR
CELL CULTURES
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CHROMOSOME BREAKAGE
CONNECTIVE TISSUE CELLS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HEREDITARY DISEASES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTATIONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PYRIMIDINES
RADIOSENSITIVITY
RIBOSIDES
SOMATIC CELLS
URACILS