Phase I and pharmacologic study of oral Ftorafur and x ray therapy in advanced gastrointestinal cancer

Journal Article · Thu Feb 28 23:00:00 EST 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90194-4· OSTI ID:5608534

Byfield, J E; Sharp, T R; Hornbeck, C L; Frankel, S S; Floyd, R A; Griffiths, J C

The authors have treated 15 patients with advanced gastrointestinal carcinoma with a cyclical regimen of combined Ftorafur (N/sub 1/-((2-furanidyl-))-5-Fluorouracil, a 5-FU pro-drug) and external beam radiation. The most common toxicity in general, and the most common limiting toxicity was nausea and vomiting, in contrast to oral FT alone where diarrhea is more prominent. Stomatitis was seen only once and no other form of serious toxicity was encountered. Two-thirds of the patients responded in subjective terms (pain relief). There was 1 partial response of FT alone (pulmonary metastases outside the treatment field). The sole patient whose treatment field was outside the abdomen (chest portals for esophageal carcinoma) developed pneumonitis which contributed to his death. No other delayed effects were noted. Serum FT levels were related to the infested dose and in the microgram range while serum 5-FU levels were in the nanogram range indicating slow decomposition of FT into 5-FU.

• Research Organization: Univ. of California, San Diego
• OSTI ID: 5608534
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 11:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMETABOLITES
AZINES
CARCINOMAS
DIARRHEA
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
FLUOROURACILS
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PAIN
PATIENTS
PHARMACOLOGY
PNEUMONITIS
PYRIMIDINES
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
SYMPTOMS
THERAPY
URACILS
VOMITING
X RADIATION