Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease
Journal Article
·
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
- National Cancer Institute, Frederick, MD (USA)
The human ETS2 gene, a member of the ETS gene family, with sequence homology with the retroviral ets sequence of the avian erythroblastosis retrovirus E26 is located on chromosome 21. Molecular genetic analysis of Down syndrome (DS) patients with partial trisomy 21 allowed us to reinforce the supposition that ETS2 may be a gene of the minimal DS genetic region. It was originally proposed that a duplication of a portion of the DS region represents the genetic basis of Alzheimer disease, a condition associated also with DS. No evidence of either rearrangements or duplications of ETS2 could be detected in DNA from fibroblasts and brain tissue of Alzheimer disease patients with either the sporadic or the familiar form of the disease. Thus, an altered ETS2 gene dosage does not seem to be a genetic cause or component of Alzheimer disease.
- OSTI ID:
- 5606497
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 85:20; ISSN 0027-8424; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550401* -- Genetics-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADULTS
AGE GROUPS
ANEUPLOIDY
ANIMAL CELLS
AUTORADIOGRAPHY
BIOLOGY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
CONGENITAL MALFORMATIONS
CONNECTIVE TISSUE CELLS
DISEASES
DNA
DOWNS SYNDROME
FIBROBLASTS
GENES
GENETICS
HEREDITARY DISEASES
HUMAN CHROMOSOME 21
HYBRIDIZATION
KARYOTYPE
MALFORMATIONS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEIC ACIDS
ONCOGENES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PLOIDY
RFLPS
SOMATIC CELLS
59 BASIC BIOLOGICAL SCIENCES
ADULTS
AGE GROUPS
ANEUPLOIDY
ANIMAL CELLS
AUTORADIOGRAPHY
BIOLOGY
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
CONGENITAL MALFORMATIONS
CONNECTIVE TISSUE CELLS
DISEASES
DNA
DOWNS SYNDROME
FIBROBLASTS
GENES
GENETICS
HEREDITARY DISEASES
HUMAN CHROMOSOME 21
HYBRIDIZATION
KARYOTYPE
MALFORMATIONS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEIC ACIDS
ONCOGENES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PLOIDY
RFLPS
SOMATIC CELLS