Human ETS2 gene on chromosome 21 is not rearranged in Alzheimer disease

Journal Article · Sat Oct 01 00:00:00 EDT 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.85.20.7675· OSTI ID:5606497

Sacchi, N; Nalbantoglu, J; Sergovich, F R; Papas, T S ^[1]

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1. National Cancer Institute, Frederick, MD (USA)

The human ETS2 gene, a member of the ETS gene family, with sequence homology with the retroviral ets sequence of the avian erythroblastosis retrovirus E26 is located on chromosome 21. Molecular genetic analysis of Down syndrome (DS) patients with partial trisomy 21 allowed us to reinforce the supposition that ETS2 may be a gene of the minimal DS genetic region. It was originally proposed that a duplication of a portion of the DS region represents the genetic basis of Alzheimer disease, a condition associated also with DS. No evidence of either rearrangements or duplications of ETS2 could be detected in DNA from fibroblasts and brain tissue of Alzheimer disease patients with either the sporadic or the familiar form of the disease. Thus, an altered ETS2 gene dosage does not seem to be a genetic cause or component of Alzheimer disease.

• OSTI ID: 5606497
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 85:20; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DNA
HYBRIDIZATION
NERVOUS SYSTEM DISEASES
GENETICS
ONCOGENES
ANEUPLOIDY
ADULTS
AUTORADIOGRAPHY
BRAIN
DOWNS SYNDROME
FIBROBLASTS
HEREDITARY DISEASES
HUMAN CHROMOSOME 21
KARYOTYPE
PATIENTS
RFLPS
AGE GROUPS
ANIMAL CELLS
BIOLOGY
BODY
CENTRAL NERVOUS SYSTEM
CHROMOSOMES
CONGENITAL MALFORMATIONS
CONNECTIVE TISSUE CELLS
DISEASES
GENES
MALFORMATIONS
NERVOUS SYSTEM
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PLOIDY
SOMATIC CELLS
550401* - Genetics- Tracer Techniques