Mutagenic and clastogenic properties of 3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone: a potent bacterial mutagen in drinking water
Journal Article
·
· Environ. Mol. Mutagen.; (United States)
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) was found to be a direct-acting mutagen in the Ames test for strains TA1535, TA1538, TA92, TA97, TA98, TA100 and TA102. The highest mutagenic response (approximately 13,000 revertants/nmol) was seen in strain TA100. The TA100 response was six- to tenfold higher than in TA98, TA97, and TA102, and 100- to 500-fold higher than in TA1535, TA92, and TA1538. The addition of a 9,000 x g supernatant fraction (S-9) from livers of polychlorinated biphenyl-treated rats, along with cofactors for NADPH generation, resulted in a 90% reduction in the TA100 mutagenicity. MX induced chromosomal aberrations in Chinese hamster ovary cells after 6-8 hr exposure without S-9 at a dose as low as 4 micrograms/ml, and after 2 hr exposure with S-9 at a dose of 75 micrograms/ml. The oral dose of MX lethal to 50% (LD50) in Swiss-Webster mice was determined to be 128 mg/kg. MX did not induce micronuclei in mouse bone marrow when administered by oral gavage at doses up to 70% of the LD50.
- Research Organization:
- Environmental Protection Agency, Cincinnati, OH
- OSTI ID:
- 5605928
- Journal Information:
- Environ. Mol. Mutagen.; (United States), Journal Name: Environ. Mol. Mutagen.; (United States) Vol. 10:4; ISSN ENMUE
- Country of Publication:
- United States
- Language:
- English
Similar Records
Salmonella typhimurium (TA100) mutagenicity of 3-chloro-4(dichloromethyl)-5-hydroxy-2(5H)-furanone and its open- and closed-ring analogs
Induction of gastrointestinal tract nuclear anomalies in B6C3F1 mice by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and 3,4(dichloro)-5-hydroxy-2(5H)-furanone, mutagenic byproducts of chlorine disinfection
Determination of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in chlorinated drinking and humic waters
Journal Article
·
Mon Dec 31 23:00:00 EST 1990
· Environmental and Molecular Mutagenesis; (USA)
·
OSTI ID:5623882
Induction of gastrointestinal tract nuclear anomalies in B6C3F1 mice by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone and 3,4(dichloro)-5-hydroxy-2(5H)-furanone, mutagenic byproducts of chlorine disinfection
Journal Article
·
Mon Dec 31 23:00:00 EST 1990
· Environmental and Molecular Mutagenesis; (USA)
·
OSTI ID:5623900
Determination of the strong mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in chlorinated drinking and humic waters
Journal Article
·
Tue Dec 31 23:00:00 EST 1985
· Chemosphere; (United States)
·
OSTI ID:5089859
Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BACTERIA
BODY
BONE MARROW
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DRINKING WATER
FIBROBLASTS
FURANS
GLANDS
HAMSTERS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
LIVER
MAMMALS
MICE
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SOMATIC CELLS
TISSUES
VERTEBRATES
WATER
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BACTERIA
BODY
BONE MARROW
CHO CELLS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
DRINKING WATER
FIBROBLASTS
FURANS
GLANDS
HAMSTERS
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
LIVER
MAMMALS
MICE
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RATS
RODENTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING
SOMATIC CELLS
TISSUES
VERTEBRATES
WATER