Technetium-99m haemaccel: A new lymphoscintigraphic agent

Journal Article · Sun Jan 01 04:00:00 EST 1989 · American Journal of Physiologic Imaging; (USA)

OSTI ID:5605821

Sadek, S; Owunwanne, A; Yacoub, T; Abdel-Dayem, H M ^[1]

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1. Kuwait Univ., Safat

Haemaccel, a denatured gelatin polymer with average molecular weight of 35,000, was labeled with Tc-99m and evaluated in rats and rabbits. The labeling efficiency was consistently higher than 85%. Tc-99m haemaccel (200 microCi in 0.05 ml) was injected intradermally into the hind footpads of rats lightly anaesthetized with diethyl ether vapour. Using a gamma camera, static images of the anterior view were obtained at various time intervals after injection. The images obtained demonstrated good localization of Tc-99m haemaccel in regional lymph nodes. In rats, about 3% of the injected dose was trapped in the node, and 48% remained at the injection site at 4 h after injection. In rabbits, good-quality images of lymph nodes and lymphatic channels of the hind legs were obtained within 15 min after intradermal injection of Tc-99m haemaccel. Tc-99m haemaccel showed fast migration from the injection site, good accumulation in the lymph nodes, and good visualization of lymphatic channels. Hence, it has a potential application in lymphoscintigraphy.

• OSTI ID: 5605821
• Journal Information: American Journal of Physiologic Imaging; (USA), Journal Name: American Journal of Physiologic Imaging; (USA) Vol. 4:2; ISSN 0885-8276; ISSN AJPIE
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CONTRAST MEDIA
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DRUGS
EFFICIENCY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LYMPHATIC SYSTEM
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
POLYMERS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RODENTS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES