Seventeen-year mortality experience of proton radiation in Macaca mulatta

Journal Article · Mon Apr 01 04:00:00 EST 1985 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576426· OSTI ID:5605718

Yochmowitz, M G; Wood, D H; Salmon, Y L

This is an interim report on the lifetime study of chronic mortality and its causes under investigation in 31 control (20 males, 11 females) and 217 survivors (124 males, 93 females) of an acute 90-day experiment in rhesus monkeys. Single acute whole-body exposures were made using 32-, 55-, 138-, 400-, and 2300-MeV protons in 1964-1965. Doses ranged from 25 to 800 rad and dose rates from 12.5 and 100 rad per minute. For pooled data: (1) mortality was signigicantly higher in irradiated animals (48%) than in controls (19%); (2) mortality in animals exposed to partially penetrating 55-MeV protons was essentially similar to those given totally penetrating 138-, 400-, and 2300-MeV exposures; (3) proton energies and doses that were effective in producing life shortening were greater than or equal to 55 MeV and greater than or equal to 360-400 rad, respectively; (4) death rates for irradiated animals compared to controls began to increase after approx.8 years, approx.2 years, and approx.1 year for those exposed to 360-400, 500-650, and 800 rad, respectively; (5) of the nine probable causes of death reported, the leading causes were primary infections in both irradiated and control animals, endometriosis, neoplasms, and organ degeneration; and (6) if endometriosis is included with the neoplastic group, deaths from all forms of neoplasms would be 42% in irradiated animals. From the results of this study, it is reasonable to conclude that development of endometriosis in females and neoplasms in males is enhanced significantly by proton irradiation over that of respective controls.

• Research Organization: USAF School of Aerospace Medicine, Brooks AFB, TX
• OSTI ID: 5605718
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 102:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DATA
DELAYED RADIATION EFFECTS
DISEASES
ELEMENTARY PARTICLES
ENERGY RANGE
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FEMALE GENITALS
FERMIONS
HADRONS
HEART
INFECTIOUS DISEASES
INFORMATION
IRRADIATION
MAMMALS
MEV RANGE
MEV RANGE 10-100
MEV RANGE 100-1000
MONKEYS
MORTALITY
MUSCLES
NEOPLASMS
NERVOUS SYSTEM
NUCLEONS
NUMERICAL DATA
ORGANS
PRIMATES
PROTONS
RADIATION EFFECTS
RADIOINDUCTION
SKELETON
UTERUS
VERTEBRATES
WHOLE-BODY IRRADIATION