Gated blood-pool studies of cardiac function in the rat and marmoset
To develop a sensitive, relatively noninvasive method for monitoring cardiac function in small laboratory animals, equilibrium gated blood-pool imaging (with Tc-99m RBC) was adapted for use in an inbred strain of laboratory rats of 400-470 g body weight and in marmosets of 320-400 g body weight. A 2-mm pinhole collimator was fitted to the gamma camera to produce a distinct image of the left ventricle following intravenous injection of 5 mCi of pertechnetate. Reproducible and consistent data for heart rate, left-ventricular ejection fraction, and peak ejection rate were obtained from studies on 13 male rats and five marmosets maintained on constant diets. An intravenous injection of 0.4 microgram of isoprenaline led to predictable increases in heart rate, left-ventricular ejection fraction, and peak ejection rate, and provided evidence of the sensitivity of the method in monitoring heart function in small laboratory animals.
- Research Organization:
- CSIRO, Div. of Human Nutrition, Glenthorne Laboratories, Adelaide, South Australia
- OSTI ID:
- 5605327
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 24:8
- Country of Publication:
- United States
- Language:
- English
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HEART
DYNAMIC FUNCTION STUDIES
TECHNETIUM 99
TRACER TECHNIQUES
CARDIOGRAPHY
GAMMA CAMERAS
ISOMERIC NUCLEI
MALES
MONKEYS
PERTECHNETATES
RADIOISOTOPE SCANNING
RATS
SYMPATHOMIMETICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CAMERAS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PRIMATES
RADIOISOTOPES
RODENTS
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques