Peribronchiolar fibrosis in lungs of cats chronically exposed to diesel exhaust

Journal Article · Fri Feb 01 00:00:00 EST 1985 · Lab. Invest.; (United States)

OSTI ID:5603527

Hyde, D M; Plopper, C G; Weir, A J; Murnane, R D; Warren, D L; Last, J A; Pepelko, W E

This study reports the quantitative changes in the pulmonary proximal acinar region following chronic exposure to diesel exhaust and following an additional 6 months in clean air. Cats (13 months of age) from a minimum disease colony were exposed to clean air (eight cats for 27 months and nine cats for 33 months), diesel exhaust for 8 hours/day, 7 days/week (nine cats for 27 months), or diesel exhaust for 27 months followed by 6 months in clean air (10 cats). Morphologic and morphometric evaluation using light microscopy and scanning and transmission electron microscopy revealed two major exposure-related lesions in proximal acinar regions of lungs of cats: peribronchiolar fibrosis associated with significant increases in lymphocytes, fibroblasts, and interstitial macrophages containing diesel particulate-like inclusions and bronchiolar epithelial metaplasia associated with the presence of ciliated and basal cells and alveolar macrophages containing diesel particulate-like inclusions. Peribronchiolar fibrosis was greater at the end of the 6 months in clean air following exposure, whereas the bronchiolar epithelial metaplasia was most severe at the end of exposure. Following an additional 6 months in clean air the epithelium more closely resembled the control epithelial cell population. The labeling index of terminal bronchiolar epithelium was significantly increased at the end of exposure but was not significantly different from controls or exposed cats following an additional 6 months in clean air. The ultrastructural appearance of epithelial cells remained relatively unchanged following diesel exhaust exposure with the exception of diesel particulate-like inclusions.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5603527
• Journal Information: Lab. Invest.; (United States), Vol. 52:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DIESEL ENGINES
EXHAUST GASES
TOXICITY
LUNGS
FIBROSIS
AUTORADIOGRAPHY
CATS
CHRONIC EXPOSURE
ELECTRON MICROSCOPY
EPITHELIUM
FIBROBLASTS
LYMPHOCYTES
MACROPHAGES
ULTRASTRUCTURAL CHANGES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ENGINES
FLUIDS
GASEOUS WASTES
GASES
HEAT ENGINES
INTERNAL COMBUSTION ENGINES
LEUKOCYTES
MAMMALS
MATERIALS
MICROSCOPY
MORPHOLOGICAL CHANGES
ORGANS
PATHOLOGICAL CHANGES
PHAGOCYTES
RESPIRATORY SYSTEM
SOMATIC CELLS
TISSUES
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550901 - Pathology- Tracer Techniques