Remodelling glycoforms on proteins and cells by chemoselective ligation
Conference
·
OSTI ID:560329
- Univ. of California, Berkeley, CA (United States)
The chemoselective ligation strategy has found tremendous success in the synthesis of macromolecular protein conjugates. At the heart of this approach is the introduction of mutually and uniquely reactive functional groups onto unprotected fragments and the coupling of these fragments in an aqueous environment. We have extended the principle of chemoselective ligation to the generation of glycoproteins and cells with tailor-made glycoforms. New enzymatic and biosynthetic methods for introducing uniquely reactive functional groups onto protein-bound oligosaccharides will be presented, along with applications to glycoform engineering.
- OSTI ID:
- 560329
- Report Number(s):
- CONF-970443--
- Resource Type:
- Conference proceedings
- Conference Information:
- 213. national meeting of the American Chemical Society, San Francisco, CA (United States), 13-17 Apr 1997; Is Part Of 213th ACS national meeting; PB: 2904 p.
- Country of Publication:
- United States
- Language:
- English
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