Effect of the size of the dose on the distribution and excretion of mercury in rats after single intravenous injection of various mercury compounds

Journal Article · Wed Jan 01 04:00:00 EST 1969 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(69)90053-2· OSTI ID:5603165

Ulfvarson, U

The effect of the size of the dose on the distribution and excretion of mercury in rats after single intravenous injections of each of four mercury compounds has been investigated. The mercury compounds were methylmercury hydroxide, methoxyethylmercury hydroxide, phenylmercury hydroxide, and mercuric nitrate. These compounds labeled with /sup 203/Hg were injected at doses corresponding to about 0.1, 1, and 10% of the LD50. The concentrations of mercury in the organs were analyzed by scintillation technique at different times after injection. The principle of superposition, which is usually followed by stable compounds in the bodies of experimental animals, states that concentrations in the various organs should be proportional to the dose at any given time after the injection. It was found that, except for methylmercury hydroxide, the investigated compounds deviated from this simple relationship. The relations between the concentrations in the organs at different doses indicated a saturation phenomenon and an increase in the rate of excretion when the size of the dose was increased. 9 references, 8 tables.

• Research Organization: King Gustaf V Research Institute, Stockholm, Sweden
• OSTI ID: 5603165
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 15; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOSE-RESPONSE RELATIONSHIPS
EVEN-ODD NUCLEI
EXCRETION
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MERCURY 203
MERCURY COMPOUNDS
MERCURY ISOTOPES
MERCURY NITRATES
NITRATES
NITROGEN COMPOUNDS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
OXYGEN COMPOUNDS
RADIOISOTOPES
RATS
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES