Prevention of the formation of arterial thrombi using different antiplatelet drugs: Experimental study in dogs

Journal Article · Mon May 01 04:00:00 EDT 1989 · Thromb. Res.; (United States)

DOI:https://doi.org/10.1016/0049-3848(89)90226-0· OSTI ID:5602908

Escudero-Vela, M C; Alvarez, L; Rodriguez, V; del Moral, J H; Millan, I; Castillo-Olivares, J L

We have induced the formation of arterial thrombosis in dogs by means of an intima lesion produced by continuous current. The platelets were labeled with 111-In-oxine. Groups of 7 mongrel dogs received treatment for 7 days prior to the trial: Group I, control; Group II, 5 mg/kg body weight/day acetylsalicylic acid; Group III, 20 mg/kg body wt/day acetylsalicylic acid; Group IV, 15 mg/kg body wt/day triflusal + 5 mg/kg body wt/day dipyridamole; Group V, 15 mg/kg body wt/day triflusal; and Group VI, 5 mg/kg body wt/day acetylsalicylic acid + 5 mg/kg body wt/day dipyridamole. The only effective treatment for arterial thrombosis prevention was that employed in Group II (p less than 0.05).

• Research Organization: Clinica Puerta de Hierro, Madrid (Spain)
• OSTI ID: 5602908
• Journal Information: Thromb. Res.; (United States), Journal Name: Thromb. Res.; (United States) Vol. 54:3; ISSN THBRA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACETYLSALICYLIC ACID
ANALGESICS
ANIMALS
ANTIPYRETICS
AROMATICS
AZAARENES
AZINES
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
HYDROXY COMPOUNDS
INDIUM 111
INDIUM ISOTOPES
INHIBITION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXINE
PREVENTIVE MEDICINE
PYRIDINES
QUINOLINES
RADIOISOTOPES
SCINTILLATION COUNTING
THROMBOSIS
TRACER TECHNIQUES
VASCULAR DISEASES
VASODILATORS
VERTEBRATES