Selenium in forage crops and cancer mortality in U. S. counties

Journal Article · · Archives of Environmental Health; (USA)

DOI:https://doi.org/10.1080/00039896.1991.9937427· OSTI ID:5601620

Clark, L C ^[1]; Cantor, K P ^[2]; Allaway, W H ^[3]

---

1. Univ. of Arizona, Tucson (USA)
2. National Cancer Institute, Bethesda, MD (USA)
3. United States Department of Agriculture, Ithaca, NY (USA)

The potential protective effect of selenium status on the risk of developing cancer has been examined in animal and epidemiologic studies. This ecological study investigated the association between U.S. county forage selenium status and site- and sex-specific county cancer mortality rates (1950-1969) using weighted least squares regression. Consistent, significant (p<.01) inverse associations were observed for cancers of the lung, rectum, bladder, esophagus, and cervix in a model limited to rural counties and for cancers of the lung, breast, rectum, bladder, esophagus, and corpus uteri in a model of all counties. No consistent significant positive associations were observed in the rural county models. This remarkable degree of consistency for the inverse associations strengthens the likelihood of a causal relationship between low selenium status and an increased risk of cancer mortality.

• OSTI ID: 5601620
• Journal Information: Archives of Environmental Health; (USA), Journal Name: Archives of Environmental Health; (USA) Vol. 46:1; ISSN AEHLA; ISSN 0003-9896
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism &amp; Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL FEEDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BLADDER
BODY
CARCINOGENESIS
CROPS
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
EPIDEMIOLOGY
ESOPHAGUS
FEMALE GENITALS
FOOD
FORAGE
GASTROINTESTINAL TRACT
INTESTINES
LARGE INTESTINE
LUNGS
MAMMALS
MAN
MORTALITY
NEOPLASMS
NUTRITIONAL DEFICIENCY
ORGANS
PATHOGENESIS
PRIMATES
RECTUM
RESPIRATORY SYSTEM
SELENIUM
SEMIMETALS
URINARY TRACT
VERTEBRATES