Gallium lung scanning and bronchoalveolar lavage in crocidolite-exposed workers
Gallium lung scanning is widely used to evaluate pulmonary inflammation in patients with interstitial lung disease but has not previously been reported in crocidolite-exposed workers. In order to characterize the pulmonary inflammation caused by crocidolite inhalation, GLS and BAL findings were related to chest x-ray film changes graded according to the ILO classification of roentgenograms of pneumoconioses. In individuals with roentgenographic evidence of asbestosis (CXR greater than or equal to 1/0, n = 15), 13 had a positive GLS and 13 had an abnormal BAL. In asbestos-exposed individuals with equivocal chest x-ray film changes (CXR 0/1, n = 12), six had a positive GLS and six had BAL changes (both GLS and BAL abnormal in three). In individuals with a normal chest x-ray film (CXR 0/0 n = 8), two had a positive GLS and two BAL changes (both abnormal in 1). These data demonstrate that most subjects with crocidolite-induced asbestosis have an abnormal GLS and BAL. In addition, many individuals with asbestos exposure and equivocal or no chest x-ray film changes have an abnormal GLS and/or BAL, suggesting the presence of active subclinical pulmonary inflammation in these individuals.
- Research Organization:
- Sir Charles Gairdner Hospital, Nedlands (Australia)
- OSTI ID:
- 5600556
- Journal Information:
- Chest; (United States), Vol. 96:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ASBESTOS
TOXICITY
LUNGS
RADIOISOTOPE SCANNING
RESPIRATORY SYSTEM DISEASES
DIAGNOSIS
BIOMEDICAL RADIOGRAPHY
CITRATES
GALLIUM ISOTOPES
LAVAGE
MINING
OCCUPATIONAL EXPOSURE
PERSONNEL
X RADIATION
BODY
CARBOXYLIC ACID SALTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
ORGANS
RADIATIONS
RADIOLOGY
RESPIRATORY SYSTEM
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560300 - Chemicals Metabolism & Toxicology
550602 - Medicine- External Radiation in Diagnostics- (1980-)