Studies of tracheal secretion in organophosphate poisoned swine
Thesis/Dissertation
·
OSTI ID:5598872
The organophosphates (OP), DFP, Soman, Sarin, and VX, were given daily to male swine at an initial dosage of 2 mg, 3 ug, 15 ug and 10 ug per Kg and followed by a maintenance dosage of 1 mg, 1 ug, 5 ug and 3 ug per Kg for up to 7 days, respectively. Muscarinic receptor (mAChR) density and acetylcholinesterase (AChE) activity were determined in tracheal submucosal gland cells (TSGC) isolated by collagenase and Percoll density gradient centrifugation. The biochemical properties of mAChR were determined using ({sup 3}H)quinuclidinyl benzilate (({sup 3}H)QNB) and ({sup 3}H)N-methylscopolamine (({sup 3}H)NMS) as ligands.
- Research Organization:
- Mississippi Univ., University, MS (USA)
- OSTI ID:
- 5598872
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
CARBOXYLESTERASES
CENTRIFUGATION
CHEMICAL PROPERTIES
CHOLINESTERASE
DOMESTIC ANIMALS
DRUGS
ENZYME ACTIVITY
ENZYMES
ESTERASES
HYDROGEN COMPOUNDS
HYDROLASES
ISOTOPE APPLICATIONS
KINETICS
LIGANDS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PROTEINS
REACTION KINETICS
RECEPTORS
RESPIRATORY SYSTEM
SECRETION
SEPARATION PROCESSES
SWINE
SYMPATHOMIMETICS
TOXICITY
TRACER TECHNIQUES
TRACHEA
TRITIUM COMPOUNDS
ULTRACENTRIFUGATION
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
CARBOXYLESTERASES
CENTRIFUGATION
CHEMICAL PROPERTIES
CHOLINESTERASE
DOMESTIC ANIMALS
DRUGS
ENZYME ACTIVITY
ENZYMES
ESTERASES
HYDROGEN COMPOUNDS
HYDROLASES
ISOTOPE APPLICATIONS
KINETICS
LIGANDS
MAMMALS
MEMBRANE PROTEINS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PROTEINS
REACTION KINETICS
RECEPTORS
RESPIRATORY SYSTEM
SECRETION
SEPARATION PROCESSES
SWINE
SYMPATHOMIMETICS
TOXICITY
TRACER TECHNIQUES
TRACHEA
TRITIUM COMPOUNDS
ULTRACENTRIFUGATION
VERTEBRATES