Relation of polychlorinated biphenyls to birthweight and gestational age in the offspring of occupationally exposed mothers

Technical Report · Thu Sep 20 04:00:00 EDT 1984

OSTI ID:5596601

Taylor, P R; Stelma, J; Lawrence, C E

A study was made of the relation between occupational exposure of women to high homolog polychlorinated biphenyls (PCB) and birthweight and gestational age among the live offspring of these workers. In 1982 interviews were conducted with 200 women who had held jobs with direct PCB exposure. A comparison was made with 205 women who had never held such a job. When all births occurring to mothers following exposure to PCBs were considered, the unadjusted mean birthweight in the direct exposure group was 96 grams less than the comparison group. No differences in gestational age were seen between groups. The birthweight difference was reduced to 41 grams following adjustment for potential confounding factors. In a parallel analysis using a continuous exposure variable estimate generated from an independently derived serum PCB prediction model, no effect of PCBs was noted on birthweight or gestational age using either crude or adjusted analyses. The authors conclude that no evidence for a biologically meaningful effect of high homolog PCBs on gestational age or birthweight exists.

• Research Organization: New York State Dept. of Health, Albany, NY (United States). Wadsworth Center for Labs. and Research
• OSTI ID: 5596601
• Report Number(s): PB-92-133297/XAB; CNN: PHS-210-81-5102
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
CHLORINATED AROMATIC HYDROCARBONS
FEMALES
HALOGENATED AROMATIC HYDROCARBONS
MAMMALS
MAN
MATHEMATICS
OCCUPATIONAL EXPOSURE
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PRIMATES
PROGENY
REGRESSION ANALYSIS
STATISTICS
TERATOGENESIS
VERTEBRATES
WOMEN