Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Analysis of late complications after rapid hyperfractionated radiotherapy in advanced head and neck cancers

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
; ; ; ; ;
Late effects were analyzed in a series of 39 patients with a 2-year minimal follow-up who were treated by rapid hyperfractionated radiotherapy. The total dose was 66-72 Gy delivered in two series of 33-36 Gy separated by a 2-4 week rest interval. The number of daily fractions ranged from 8 to 6 and the interval between each fraction was 2 hr. Late complications consisted of cervical fibrosis, mucosal necrosis, bone necrosis, trismus, and laryngeal edema. Seventy percent of patients experienced late complications, and in 54% of cases, these reactions were considered severe, causing death in 13% of patients. No relationship was found between field sizes, dosimetric data and type and frequency of late effects. It is therefore suggested that the interval between two daily sessions in any multifractionated protocol may be of critical importance.
Research Organization:
Institut Jean-Godinot, Reims, France
OSTI ID:
5592753
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 14:1; ISSN IOBPD
Country of Publication:
United States
Language:
English

Similar Records

Rapid hyperfractionated radiotherapy. Clinical results in 178 advanced squamous cell carcinomas of the head and neck
Journal Article · Mon Jul 01 00:00:00 EDT 1985 · Cancer (Philadelphia); (United States) · OSTI ID:5244699
Hyperfractionated radiotherapy in advanced squamous cell carcinoma of the head and neck
Journal Article · Mon Feb 28 23:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:5651956
Complications of head and neck radiation therapy and their management
Journal Article · Thu Mar 31 23:00:00 EST 1983 · J. Prosthet. Dent.; (United States) · OSTI ID:5849446

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DELAYED RADIATION EFFECTS
DISEASES
DOSES
FRACTIONATED IRRADIATION
HEAD
INJURIES
IRRADIATION
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
POST-IRRADIATION EXAMINATION
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY