Diagnostic efficiency of gallium 67 citrate scans in Hodgkin's disease

Journal Article · · Ann. Clin. Lab. Sci.; (United States)

OSTI ID:5587053

Kotlyarov, E V; Elson, J D; Quaife, M A

The findings of 49 67Ga citrate scans were correlated with all clinical information obtained by other diagnostic modalities in untreated and treated patients with histopathologically proven Hodgkin's disease (539 sites). Eleven nodal and extranodal sites were analyzed in terms of sensitivity, specificity, accuracy and, subsequently, by calculations of the posterior probability for the presence of disease at positive and negative sites by scan using Bayes' theorem. Lowest posterior probabilities for the presence of disease at positive sites were seen in lung parenchyma (66 percent) and spleen (67 percent) in untreated patients and for treated patients in adbominal nodes an inguinal nodes (both 66 percent), whereas the scan was a good method for detecting Hodgkin's disease at all other sites where posterior probabilities were near 100 percent. Figures for the posterior probability of disease at negative sites by scan showed it was a good modality for ruling out Hodgkin's involvement in axillary nodes, perihilar nodes, lung parenchyma, inguinal nodes, and bone marrow (all less than 10 percent); however, it was not as satisfactory in ruling out disease in untreated cervical nodes (20 percent), supraclavicular nodes (11 percent), and especially in the intraabdominal sites of spleen (35 percent), abdominal nodes (33 percent), and periaortic nodes (27 percent).

• OSTI ID: 5587053
• Journal Information: Ann. Clin. Lab. Sci.; (United States), Journal Name: Ann. Clin. Lab. Sci.; (United States) Vol. 11:2; ISSN ACLSC
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
HODGKINS DISEASE
INTERMEDIATE MASS NUCLEI
ISOTOPES
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOMAS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGY
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SCINTISCANNING
SPLEEN
USES