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Radiation associated hyperthyroidism in patients with gynecological malignancies

Journal Article · · J. Med. (Westbury, N.Y.); (United States)
OSTI ID:5584884
; ; ; ; ;

To determine the effect of abdominal and/or pelvic irradiation for gynecological malignancies on the later development of hyperthyroidism, 1,884 medical records of the patients diagnoses as carcinomas of cervix and corpus uteri, and of ovary were reviewed. Among 1,269 patients with radiation therapy, 5 patients developed hyperthyroidism after irradiation to the abdomen and/or pelvis. This is a statistically significant increase when compared with an epidemiological study. Radiation dose to the thyroid was estimated to be 30 to 200 rads. Two other patients who were irradiated to the nose or supraclavicular region in addition to the abdomen also developed hyperthyroidism. However, none of 581 patients without radiation therapy became hyperthyroid. The results indicate that radiation therapy for treatment of gynecological malignancy gives a significant radiation exposure with an increase in the incidence of subsequent hyperthyroidism.

Research Organization:
Roswell Park Memorial Institute, Buffalo, NY
OSTI ID:
5584884
Journal Information:
J. Med. (Westbury, N.Y.); (United States), Journal Name: J. Med. (Westbury, N.Y.); (United States) Vol. 5-6; ISSN JNMDB
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABDOMEN
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
DISEASES
DOSES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
EPIDEMIOLOGY
FACE
FEMALE GENITALS
GLANDS
GONADS
HEAD
HYPERTHYROIDISM
INJURIES
MEDICINE
NEOPLASMS
NOSE
NUCLEAR MEDICINE
ORGANS
OVARIES
PATIENTS
PELVIS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY
THYROID
UTERUS