Synthesis of catechol estrogens by human uterus and leiomyoma
Journal Article
·
· Steroids; (United States)
Homogenates of human endometrial, myometrial and leiomyoma tissues were incubated with (2,4,6,7-/sub 3/H)-estradiol and tritiated catechol estrogens were isolated and identified. Though 2- and 4-hydroxylations were about the same in endometrium, 4-hydroxylation was two to four fold higher than 2-hydroxylation in myometrium and leiomyoma. However, endometrium showed greater capacity to form both 2- and 4-hydroxyestrogens than the other two tissues. Both 2- and 4-hydroxylations were significantly less than in myometrium. In view of the reports indicating that inhibitors of catechol 0-methyl transferase (COMT) might act as antineoplastic agents due to their interference with t-RNA methylases and since catechol estrogens inhibit COMT, the present results suggest that endogenous synthesis of catechol estrogens may play an important role in the pathophysiology of uterine leiomyoma.
- OSTI ID:
- 5584732
- Journal Information:
- Steroids; (United States), Journal Name: Steroids; (United States) Vol. 37:2; ISSN STEDA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTINEOPLASTIC DRUGS
AROMATICS
BIOSYNTHESIS
BODY
CARBON ISOTOPES
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
DEVELOPERS
DISEASES
DRUGS
ENZYMES
ESTROGENS
FEMALE GENITALS
FEMALES
HOMOGENATES
HORMONES
HYDROXY COMPOUNDS
HYDROXYLASES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHENOLS
PHYSIOLOGY
POLYPHENOLS
PRIMATES
PYROCATECHOL
QUANTITATIVE CHEMICAL ANALYSIS
STEROID HORMONES
SYNTHESIS
TRITIUM COMPOUNDS
UTERUS
VERTEBRATES
WOMEN
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTINEOPLASTIC DRUGS
AROMATICS
BIOSYNTHESIS
BODY
CARBON ISOTOPES
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
DEVELOPERS
DISEASES
DRUGS
ENZYMES
ESTROGENS
FEMALE GENITALS
FEMALES
HOMOGENATES
HORMONES
HYDROXY COMPOUNDS
HYDROXYLASES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MAN
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PHENOLS
PHYSIOLOGY
POLYPHENOLS
PRIMATES
PYROCATECHOL
QUANTITATIVE CHEMICAL ANALYSIS
STEROID HORMONES
SYNTHESIS
TRITIUM COMPOUNDS
UTERUS
VERTEBRATES
WOMEN