Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Intraperitoneal distribution of /sup 32/P-chromic phosphate suspension in the dog

Journal Article · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
; ; ;
Intraperitoneal administration of radioactive chromic phosphate suspension is receiving renewed attention as a therapeutic treatment to limit metastatic dissemination of ovarian carcinoma. Our study utilized mongrel dogs to approximate the uptake and distribution of 3.0 millicuries /sup 32/P-chromic phosphate suspension administered intraperitoneally (IP). Lymph nodes, omentum, retroperitoneum, peritoneum, diaphragm, abdominal wall muscle, pleura, spleen, liver, kidneys, lung, small intestine, and blood were sampled for liquid scintillation counting and autoradiography. Whole blood showed the least activity (1800 cpm/100 lambda at day one, declining to 2800 cpm/100 lambda by day 16). Omentum and diaphragm maintained the greatest concentrations (183 x 10/sup 6/ dpm/g and 4 x 10/sup 6/ dpm/g respectively). These initial high values were 100 times greater than the highest values found for the small intestine, abdominal wall muscle, mediastinal and retroperitoneal lymph nodes and pleura. The peritoneum increased in specific activity until day three (5.9 x 10/sup 6/ dpm/g) and then rapidly declined. Our results show that following IP administration to the dog, /sup 32/P suspension is associated with the serous membranes of the peritoneal cavity (most notably omentum, diaphragm, peritoneum, and retroperitoneum). This distribution could be valuable in adjuvant tumor therapy since serosal surfaces of the peritoneum (both visceral and parietal) and the omentum are the most common sites of tumor metastases associated with ovarian carcinoma.
Research Organization:
Univ. of Iowa Hospitals and Clinics, Iowa City
OSTI ID:
5583684
Journal Information:
Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:10; ISSN IOBPD
Country of Publication:
United States
Language:
English

Similar Records

Intraperitoneal radioactive phosphate in early ovarian carcinoma: an analysis of complications
Journal Article · Wed May 01 00:00:00 EDT 1991 · International Journal of Radiation Oncology, Biology and Physics; (USA) · OSTI ID:5544331
Adjuvant intraperitoneal chromic phosphate therapy for women with apparent early ovarian carcinoma who have not undergone comprehensive surgical staging
Journal Article · Thu Aug 15 00:00:00 EDT 1991 · Cancer (Philadelphia); (United States) · OSTI ID:5460573
Radioactivity in blood and urine following intraperitoneal instillation of chromic phosphate in patients with and without ascites
Journal Article · Sat Sep 15 00:00:00 EDT 1984 · Am. J. Obstet. Gynecol.; (United States) · OSTI ID:6303453

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARCINOMAS
COUNTING TECHNIQUES
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
EXPERIMENTAL DATA
FEMALE GENITALS
GASTROINTESTINAL TRACT
GLANDS
GONADS
INFORMATION
INJECTION
INTAKE
INTESTINES
INTRAPERITONEAL INJECTION
ISOLATED VALUES
ISOTOPES
KIDNEYS
LIGHT NUCLEI
LIVER
LUNGS
LYMPH NODES
LYMPHATIC SYSTEM
MATERIALS
MEMBRANES
MESENTERY
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
OVARIES
PERITONEUM
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
QUANTITY RATIO
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
SCINTISCANNING
SEROUS MEMBRANES
SMALL INTESTINE
SPLEEN
TIME DEPENDENCE