Initiation of fibrinolysis in alpha 2-plasmin inhibitor deficient plasma. Role of fibrin

Journal Article · Sat Mar 15 04:00:00 EST 1986 · Thromb. Res.; (United States)

DOI:https://doi.org/10.1016/0049-3848(86)90383-X· OSTI ID:5578847

Ichinose, A; Aoki, N

Plasmin activity and fibrin degradation products (FDP) are found in alpha 2-plasmin inhibitor (alpha 2-PI) deficient plasma only when clotted, but are not found when the plasma is not clotted. To determine whether fibrin itself could initiate fibrinolysis without activating coagulation enzymes, fibrin monomers were prepared and added to alpha 2-PI deficient plasma. The addition of fibrin monomers resulted in the generation of plasmin activity, a marked increase in FDP concentration, and the release of /sup 125/I from /sup 125/I-labeled fibrin monomers. Replenishment of the deficient plasma with purified alpha 2-PI abolished the effects of fibrin monomers on the initiation of fibrinolysis. Neither development of plasmin activity, increase of FDP, nor release of /sup 125/I was observed. These findings indicate that fibrinolysis can be induced by fibrin itself without activation of coagulation cascade and the induction of fibrinolysis is efficiently blocked by alpha 2-PI.

• Research Organization: Jichi Medical School, Tochigi-Ken, Japan
• OSTI ID: 5578847
• Journal Information: Thromb. Res.; (United States), Journal Name: Thromb. Res.; (United States) Vol. 6; ISSN THBRA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL MATERIALS
BLOOD
BLOOD COAGULATION
BLOOD PLASMA
BODY FLUIDS
CHEMICAL REACTIONS
COAGULANTS
DECOMPOSITION
DRUGS
ENZYME ACTIVITY
ENZYMES
FIBRIN
FIBRINOLYSIN
FIBRINOLYSIS
FIBRINOLYTIC AGENTS
HEMATOLOGIC AGENTS
HEMOSTATICS
HYDROLASES
KINETICS
MATERIALS
ORGANIC COMPOUNDS
PEPTIDE HYDROLASES
PLASMINOGEN
PROTEINS
PROTEOLYSIS
REACTION KINETICS
SCLEROPROTEINS
SERINE PROTEINASES