Chemical, microscopic, and ultrastructural characterization of the mineral deposits in tumoral calcinosis
The presence of hydroxyapatite has been determined based on ultrastructure, X-ray diffraction, electron diffraction, and chemical analysis, and confirmed by microprobe analysis in multiple deposits surgically excised from four unrelated patients with tumoral calcinosis. The chemical composition of each of the mineralized deposits resembled bone, rather than dermis, in mineral, uronic acid, total lipid, and complexed acidic phospholipid composition. No collagen abnormalities were detected. However, all of these deposits differed from normal bone mineral, being heavily mineralized and containing larger, more perfect hydroxyapatite crystals. Ultrastructurally, the crystals were both extracellular and within mononuclear cells in close proximity to dilated rough endoplasmic reticulum.
- Research Organization:
- Department of Biochemistry, Hospital For Special Surgery, New York, New York
- OSTI ID:
- 5578124
- Journal Information:
- Clin. Orthop.; (United States), Vol. 178
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
CALCINOSIS
ELECTRON DIFFRACTION
ELECTRON MICROPROBE ANALYSIS
X-RAY DIFFRACTION
NEOPLASMS
ADOLESCENTS
COLLAGEN
FEMALES
LIPIDS
PATIENTS
PHOSPHOLIPIDS
URONIC ACIDS
AGE GROUPS
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
COHERENT SCATTERING
DIFFRACTION
DISEASES
ESTERS
MICROANALYSIS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PATHOLOGICAL CHANGES
PROTEINS
SCATTERING
SCLEROPROTEINS
550900* - Pathology
550602 - Medicine- External Radiation in Diagnostics- (1980-)