Effect of acclimation to caging on nephrotoxic response of rats to uranium

Journal Article · Sat Feb 01 00:00:00 EST 1986 · Lab. Anim. Sci.; (United States)

OSTI ID:5575527

Damon, E G; Eidson, A F; Hobbs, C H; Hahn, F F

Animal studies of the toxicity and metabolism of radionuclides and chemicals often require housing of rats in metabolism cages for excreta collection. Response of rats to toxic substances may be affected by environmental factors such as the type of cage used. Dose-response studies were conducted to assess the effects of two types of cages on the nephrotoxic response of rats to uranium from implanted refined uranium ore (yellowcake). The LD50/21 days was 6 mg of uranium ore per kilogram body weight (6 mg U/kg). The 95% confidence limit (C.L.) was 3-8 mg U/kg for rats housed in metabolism cages beginning on the day of implantation (naive rats). However, for rats housed in metabolism cages for 21 days before implantation (acclimated rats) the LD50/21 days was 360 mg U/kg (95% C.L. = 220-650 mg U/kg), which was the same value obtained for rats housed continuously in polycarbonate cages. This significant difference (P less than 0.01) in response of naive rats compared to response of acclimated rats appeared related to a significantly lower water consumption by the naive rats.

• Research Organization: Inhalation Toxicology Research Institute, Albuquerque, NM
• OSTI ID: 5575527
• Journal Information: Lab. Anim. Sci.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
URANIUM
METABOLISM
TOXICITY
DOSE-RESPONSE RELATIONSHIPS
ENVIRONMENT
EXCRETION
RADIATION SOURCE IMPLANTS
RATS
WEIGHT
ACTINIDES
ANIMALS
CLEARANCE
ELEMENTS
IMPLANTS
MAMMALS
METALS
RADIATION SOURCES
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques