Gastrointestinal absorption of neptunium in primates: effect of ingested mass, diet, and fasting
Absorption and retention of neptunium were determined in baboons after intragastric administration of neptunium nitrate solutions at pH 1. The effects of mass, diet, and fasting on absorption were studied. At higher mass levels (400-800 micrograms Np/kg), absorption was about 1%; at lower mass intakes (0.0009-0.005 micrograms Np/kg), absorption was reduced by 10- to 20-fold. The addition of an oxidizing agent (Fe3+) increased gastrointestinal absorption and supported the hypothesis of a reduction of Np (V) when loss masses were ingested. Diets depleted of or enriched with hydroxy acids did not modify retention of neptunium but increased urinary excretion with increasing hydroxy acid content. The diet enriched with milk components reduced absorption by a factor of 5. Potatoes increased absorption and retention by a factor 5, not necessarily due to the effect of phytate. Fasting for 12 or 24 h increased retention and absorption by factors of about 3 and 10, respectively. Data obtained in baboons when low masses of neptunium were administered suggest that the f1 factor used by ICRP should be decreased. However, fasting as encountered in certain nutritional habits is a factor to be taken into consideration.
- Research Organization:
- Institut de Protection et de Surete Nucleaire, Bruyeres le Chatel, France
- OSTI ID:
- 5574792
- Journal Information:
- Radiat. Res.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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APES
RADIONUCLIDE KINETICS
NEPTUNIUM
INTESTINAL ABSORPTION
RETENTION
DIET
FASTING
MILK
TISSUE DISTRIBUTION
ABSORPTION
ACTINIDES
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
DISTRIBUTION
ELEMENTS
FOOD
MAMMALS
MATERIALS
METALS
PRIMATES
TRANSURANIUM ELEMENTS
UPTAKE
VERTEBRATES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)