Consistent associations between hepatic lesions in english sole (Parophrys vetulus) and polycyclic aromatic hydrocarbons in bottom sediment

Journal Article · Thu Nov 01 04:00:00 EST 1990 · Environmental Health Perspectives; (USA)

DOI:https://doi.org/10.1289/ehp.9089195· OSTI ID:5573681

Landahl, J T; McCain, B B; Myers, M S; Brown, D W ^[1]

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1. National Oceanographic and Atmospheric Administration, Seattle, WA (USA) Univ. of Washington, Seattle (USA)

A consistent and statistically significant association between prevalence of hepatic neoplasms in free-living sole (Parophrys vetulus) and levels of anthropogenic polycyclic aromatic hydrocarbons in bottom sediment from sites of fish capture was documented in a series of studies conducted over a period of 7 years in Puget Sound, Washington. This result strengthens the evidence supporting a causal relationship between exposure to sediment-associated hydrocarbons and development of hepatic neoplasms in this bottom-dwelling marine fish species. Prevalence of two other distinct categories of idiopathic hepatic lesions - megalocytic hepatosis and steatosis/hemosiderosis - also showed consistent, statistically significant associations with polycyclic aromatic hydrocarbon concentrations in bottom sediment, and association with prevalence of a third category (putatively preneoplastic foci of cellular alteration) approached statistical significance. On the basis of other studies, megalocytic hepatosis and foci of cellular alteration are both considered to be important precursor lesions in the stepwise histogenesis of hepatic neoplasms.

• OSTI ID: 5573681
• Journal Information: Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 89; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
AROMATICS
BIOLOGICAL EFFECTS
BODY
CHEMISTRY
DIGESTIVE SYSTEM
DISEASES
FISHES
GLANDS
HISTOLOGY
HYDROCARBONS
LIVER
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
POLYCYCLIC AROMATIC HYDROCARBONS
SEDIMENTS
SOIL CHEMISTRY
VERTEBRATES