Sensitive method to monitor trace quantities of benzanthrone in workers of dyestuff industries

Journal Article · Sat Mar 01 00:00:00 EST 1986 · J. Anal. Toxicol.; (United States)

DOI:https://doi.org/10.1093/jat/10.2.72· OSTI ID:5573577

Joshi, A; Khanna, S K; Singh, G B

Dyestuff workers coming in contact with benzanthrone (an intermediate used for the synthesis of a variety of dyes) develop skin lesions, gastritis, liver malfunctions, and sexual disturbances. A highly sensitive fluorometric method to monitor trace quantities of benzanthrone in urine, serum, and biological tissues for experimental studies, has been developed. Coupled with simple extraction and resolution, optimum fluorescence is obtained in an equal mixture of chloroform:methanol, detecting as low as 2 ng benzanthrone. This method is approximately 250 times more sensitive than currently available colorimetric assay.

• Research Organization: Industrial Toxicology Research Center, Lucknow, India
• OSTI ID: 5573577
• Journal Information: J. Anal. Toxicol.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZANTHRACENE
MEASURING METHODS
TOXICITY
CHEMICAL INDUSTRY
HEALTH HAZARDS
DYES
FLUORESCENCE
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
SOLVENTS
TRACE AMOUNTS
AROMATICS
CONDENSED AROMATICS
HAZARDS
HYDROCARBONS
INDUSTRY
LUMINESCENCE
ORGANIC COMPOUNDS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)