Mass balance method for estimating transcapillary protein transport in an extremity

Journal Article · Fri Mar 01 04:00:00 EST 1985 · J. Trauma; (United States)

DOI:https://doi.org/10.1097/00005373-198503000-00009· OSTI ID:5565880

Friedman, J J; Hing, C T

A clinical procedure for applying the mass balance method to estimate transcapillary protein transport was compared with the experimental procedure of direct tissue monitoring of the rate of /sup 125/I- albumin accumulation in the dog hindlimb under conditions of venous pressure (Pv) elevation, norepinephrine infusion, and hemorrhagic hypotension. Over a wide range of venous protein flux (0.2 to 4.6 mg/min x 100 gm), the two estimates correlated well. The correlation coefficients were 0.987, 0.962, and 0.993 for Pv elevation in the control state, during norepinephrine infusion, and following hemorrhage, respectively. Since the clinical format requires only estimates of tissue blood flow, the change in tissue volume, and the change in protein concentration easily obtained with strain gauge plethysmography and venous blood sampling, it represents a relatively innocuous procedure for estimating protein transport which should be suitable for clinical application.

• Research Organization: Indiana Univ. School of Medicine, Indianapolis
• OSTI ID: 5565880
• Journal Information: J. Trauma; (United States), Journal Name: J. Trauma; (United States) Vol. 25:3; ISSN JOTRA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALBUMINS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
BODY AREAS
CAPILLARIES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEMORRHAGE
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LIMBS
MAMMALS
MASS BALANCE
MEASURING METHODS
NEUROREGULATORS
NORADRENALINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PERMEABILITY
PROTEINS
RADIOISOTOPES
STEROID HORMONES
SYMPATHOMIMETICS
SYMPTOMS
TISSUE DISTRIBUTION
VERTEBRATES