Cell biologic studies of the subplate during the development of the mammalian cerebral cortex
This study focuses on pre- and postnatal events that may be necessary in establishing organized connections within the cat cerebral cortex. The fetal white matter beneath the cortical plate - the subplate - is shown to contain synapses and synapsin I. The likely presynaptic elements are the waiting axons from the other parts of cortex as well as the thalamus. A postsynaptic target is here identified as a transient population of neurons born between E24 and E30, based on {sup 3}H-thymidine labeling studies combined with immunohistochemistry for the neuron-specific molecule MAP2, as well as ultrastructural and neuroanatomical studies showing that these early-generated subplate neurons receive synapses and have distant projections. The subplate neurons define the subplate by their immunoreactivity for MAP2. An identity is also demonstrated between the adult remnant of the subplate neuron population and the previously described interstitial and transmitter-immunoreactive neurons within the adult cerebral cortical white matter. The subplate neurons are further developmentally correlated with extracellular matrix molecule fibronectin and in experiments in which the subplate neurons are intentionally killed, fibronectin immunostaining decreases.
- Research Organization:
- Stanford Univ., CA (USA)
- OSTI ID:
- 5561367
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
AZINES
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CATS
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
FETUSES
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
IMMUNE REACTIONS
ISOTOPE APPLICATIONS
MAMMALS
NERVE CELLS
NERVOUS SYSTEM
NUCLEOSIDES
NUCLEOTIDES
ONTOGENESIS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RIBOSIDES
SOMATIC CELLS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES