Responses of susceptible subpopulations to nitrogen dioxide. Research report, June 1983-January 1988

Technical Report · Wed Feb 01 00:00:00 EST 1989

OSTI ID:5559981

Morrow, P E; Utell, M J

Symptom responses and changes in pulmonary function were investigated in people with asthma or chronic obstructive pulmonary disease (COPD) exposed to 0.3 ppm nitrogen dioxide (NO{sub 2}) for four hours. Nonrespiratory-impaired (normal) subjects of comparable ages constituted the control groups. All exposures included periods of exercise and pulmonary function measurements. No significant symptomatic or physiological responses to NO{sub 2} could be detected in either the young or elderly control group. The asthmatic group did not manifest significant reductions in lung function after exposure to 0.3 ppm NO{sub 2}, compared to their preexposure baseline data or to their responses after a comparable four-hour exposure to air. During light exercise, subjects with COPD were progressively responsive to 0.3 ppm NO{sub 2}. Subgroup analyses within the asthmatic, COPD, and elderly normal subject groups and intergroup comparisons yielded significant findings and associations.

• Research Organization: Rochester Univ., NY (USA). School of Medicine and Dentistry
• OSTI ID: 5559981
• Report Number(s): PB-89-217749/XAB
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NITROGEN DIOXIDE
DOSE-RESPONSE RELATIONSHIPS
RESPIRATORY SYSTEM DISEASES
AIR POLLUTION
ASTHMA
ENVIRONMENTAL EXPOSURE
PROGRESS REPORT
RISK ASSESSMENT
TOXICITY
CHALCOGENIDES
DISEASES
DOCUMENT TYPES
NITROGEN COMPOUNDS
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
POLLUTION
560300* - Chemicals Metabolism & Toxicology