Pertussis toxins, other antigens become likely targets for genetic engineering
Journal Article
·
· JAMA, Journal of the American Medical Association; (United States)
Genetically engineered pertussis vaccines have yet to be fully tested clinically. But early human, animal, and in vitro studies indicate effectiveness in reducing toxic effects due to Bordetella pertussis. The licensed pertussis vaccines consists of inactivated whole cells of the organism. Although highly effective, they have been associated with neurologic complications. While the evidence continues to mount that these complications are extremely rare, if they occur at all, it has affected the public's acceptance of pertussis immunization.
- OSTI ID:
- 5556788
- Journal Information:
- JAMA, Journal of the American Medical Association; (United States), Vol. 264:18; ISSN 0098-7484
- Country of Publication:
- United States
- Language:
- English
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